DiDomenico was selected by the Toronto Maple Leafs in the sixth round (164th overall) of the 2007 NHL Entry Draft and sporadically played in the National Hockey League with the Ottawa Senators about a decade later.

After two years with Asiago, DiDomenico left Italy but remained in Europe after agreeing to join Swiss club, SCL Tigers of the then National League B for their post-season campaign on February 12, 2012.

While leading the Tigers in scoring with 38 points in 48 games, DiDomenico was reluctantly released from his contract with SCL immediately after agreeing to a two-year deal to pursue his NHL ambitions with the Ottawa Senators under former junior coach Guy Boucher on February 27, 2017.

[9] He was assigned to the Blackhawks AHL affiliate, the Rockford IceHogs, where he quickly transitioned as the club's top offensive player by posting 23 points in 22 games to end the regular season.

After the season, DiDomenico as an impending free agent, opted to recommence his European career by returning to his former Swiss club, SCL Tigers, on an optional three-year contract on June 13, 2018.