[4] Duhon arrived at Duke in 2000, where he was an important role player, playing backup to point guard Jason Williams.

In his senior season, Duhon averaged 10 points, 6 assists, 2.2 steals, and 4.1 rebounds per game, en route to another Final Four.

He left as the only Atlantic Coast Conference player to record 1,200 points, 800 assists, 475 rebounds, 300 steals, and 125 three-point shots.

In 2005, after Hurricane Katrina, Duhon's Stand Tall Foundation handed out over 3,000 boxes of supplies worth $450,000 for residents of his hometown Slidell.

[6] Duhon played a key role in the Bulls winning their first playoff series since the Michael Jordan era against the Miami Heat.

After the Bulls fell in a 3–0 hole, a deficit no team has come back from in the NBA Playoffs, Duhon played solidly off the bench.

The trade of Ben Wallace and Joe Smith to the Cleveland Cavaliers for Larry Hughes and Drew Gooden also caused a logjam in the backcourt.

In a game against the Golden State Warriors on February 7, 2008, Duhon scored a career-high 34 points along with 9 assists, 3 steals, 2 rebounds, and 4 three-pointers.

On July 4, 2008, Duhon accepted a two-year deal worth close to $12 million total to play for the New York Knicks.

On August 10, 2012, Duhon was traded to the Los Angeles Lakers along with teammates Dwight Howard and Earl Clark as part of a four-team deal.

[17] On November 30, 2015, shortly after 6 AM police officers were asked to respond to a "man down" call and found Duhon passed out in the driver's seat of his Ford Escape.

[18] Duhon was booked into the Western Regional Jail in Barboursville, West Virginia on a charge of aggravated DUI.