[1] Prior to meeting Blackie Lawless and Randy Piper, and joining W.A.S.P., Holmes played guitar with Los Angeles bands Buster Savage, LAX, and Slave.

[1] Between his stints in W.A.S.P., Holmes formed the band Psycho Squad, who recorded one demo called "Born, Work, Die" in 1991[3] with a line-up consisting of Holmes, singer Johnny Severe, ex-Against The Grain bassist Mike Kortz and ex-Citizen Kane drummer Chris Olson.

After Holmes returned to Los Angeles in late 2003, he began working with several Southern California-based metal groups, producing and contributing guitar tracks.

In 2010, Holmes joined Where Angels Suffer with Randy Piper on guitar, Steve Unger (Metal Church) on bass, Rich Lewis (Animal), on vocals, and Stet Howland on drums (Blackfoot, Lita Ford, Killing Machine, Belladonna, Impellitteri, Sister and W.A.S.P.).

On May 2, 2015, that album was released worldwide and on the same day Holmes played his first concert in Nantes, France, with his new band Mean Man.

Since 2019 Holmes has introduced new members to Mean Man: vocalist Oliver Tindall, bassist Lex Gifford and drummer Stephen Jackson.

The film details Holmes' current life while also telling the story of his rise to fame and dramatic fall due to substance abuse issues, ultimately leading to the loss of his W.A.S.P.

In early 2022, Holmes was diagnosed with throat and neck cancer, with future plans on hold due to treatment.