Latham enjoyed a breakout season with the Yakima Bears of the Northwest League in 1994, setting a club record with a .340 batting average.

Los Angeles received pitchers Kevin Tapani and Mark Guthrie from the Minnesota Twins, with Latham, Ron Coomer, Greg Hansell and José Parra going the other way.

Latham made his major league debut with the Twins on April 12, 1997, appearing as a pinch runner for Todd Walker in an 11-6 win over the Kansas City Royals.

[3] He spent parts of the next three seasons with the Twins, but struggled to establish himself in the major leagues, and was traded to the Colorado Rockies for Scott Randall on December 7, 1999.

Latham spent all of the 2000 season at the AAA level, then signed with the Toronto Blue Jays organization as a minor league free agent.