Against the University of Georgia on February 11, 2006, he made a school record 9 three-point shots en route to a career-high 33 points in an 83–78 win.

In the 2006–07 season, Lofton led the conference in scoring, with 20.8 points per game, and was named the SEC Player of the Year by the Associated Press.

Lofton was featured on the cover of the November 21, 2007 Sports Illustrated[4] issue, holding a basketball away from Chris Douglas-Roberts of the University of Memphis.

On January 22, 2008, Lofton passed Pat Bradley of the University of Arkansas to capture the record for the most career three-pointers in the Southeastern Conference with 367.

In July 2008, Lofton signed a one-year contract with Mersin Büyükşehir Belediyesi of the Turkish Basketball League.

[8] In the season 2009–10, Chris Lofton was signed by Spanish ACB League powerhouse, Caja Laboral Baskonia.

[14] In August 2011 he returned to CB Estudiantes, signing a one-year deal[15] but finally he couldn't play with the team of Madrid until January 2012 because of his physical problems.

Following the end of the 2007 season, Lofton was diagnosed with testicular cancer, which he kept a secret to all but Bruce Pearl, his parents, and a small number of university officials.