He was selected with the 26th overall pick in the first round of the 2005 NFL draft out of the University of Mississippi by the Seattle Seahawks.

His home ties led him to choose the University of Mississippi, where he played alongside Madison Central teammates Doug Buckles and Mike Espy (of the Washington Redskins).

During the 2003 season, the Ole Miss Rebels had an impressive campaign, winning 10 games concluded with a Cotton Bowl Classic victory over Oklahoma State.

[5] In Week 4 against the Carolina Panthers, Spencer subbed for Lance Louis, but would himself go out of the game with a hand injury.

[6] On November 22, 2012, Spencer was named as the Bears starting guard after Chilo Rachal was placed on the reserve/non-football injury list.