Until his retirement in January 2016, Wyles represented the United States men's national rugby sevens team in three World Cups in 2007, 2011, and 2015.

He played three positions, wing, full back, and centre, and is the most capped fullback in U.S. national team history.

[4] In the 2009-2010 season he was a regular starter on the wing, playing in the Saracens team that took on Leicester in the final of the English Premiership.

Following on from that season, Wyles became a key figure in the successful 2010-11 Premiership winning side, beating Leicester 22-18 in the Final.

[9] In the 2016-17 season, Saracens won the European Championship for a second year in a row, defeathig Clermont Auvergne 28-17, in Edinburgh.

[citation needed] In 2009, Wyles was included in the USA Eagles team of the decade by RugbyMag, a leading US rugby publication.

[16] Wyles continued his form for the USA team, playing in the 2011 Rugby World Cup in New Zealand, finishing as the Eagles top points scorer.

[citation needed] In January 2016, Wyles announced his retirement from international XVs duty with the Eagles.

[18] In August 2016, Wyles was a member of USA National Sevens Team in the Summer 2016 Olympics held in Rio de Janeiro.