She made her professional modeling debut in the annual Sports Illustrated Swimsuit Issue in 2010 and appeared on the 50th-anniversary cover alongside Nina Agdal and Lily Aldridge in 2014.

[15] She was also featured on another Cooking Channel special, titled Chrissy Teigen's Hungry, detailing her wedding menu tasting with then-fiancé, John Legend.

[17] In April 2014, Teigen played a fictionalized version of herself as a relationship counselor in an Inside Amy Schumer sketch.

[18] That same year, she appeared on the 50th anniversary cover of the Sports Illustrated Swimsuit Issue with Nina Agdal and Lily Aldridge.

[19][20] In January 2015, Teigen guest starred on the sitcom The Mindy Project as the girlfriend of the man who was the main character's first sexual partner.

[21] In April, she became a co-host of the musical competition series Lip Sync Battle alongside LL Cool J.

[23] From September 2015 until June 2016, Teigen was a food stylist and panelist on Tyra Banks's syndicated daytime talk show, FABLife.

[24] In February 2016, she published a book titled Cravings: Recipes for All of the Food You Want to Eat, which went on to become a New York Times bestseller and the second-best selling cookbook of the year.

[31] In November, she launched a cooking website, Cravings by Chrissy Teigen, which features recipes as well as restaurant and entertaining tips.

[40] A supporter of immigrants' rights, Teigen delivered a speech at a Families Belong Together event in Los Angeles that same year.

[41] In May 2020, she donated $200,000 to bail and legal defense funds to aid activists arrested during protests in response to the murder of George Floyd.

[5] On September 16, 2023, Teigen and Legend celebrated ten years of marriage and renewed their vows by Lake Como, Italy.

[53][54] While the couple was expecting a third child in 2020, Teigen experienced pregnancy loss at 20 weeks due to a complication, initially described as a miscarriage.

[61] In May 2021, television personality Courtney Stodden said that in 2011, during her marriage as a minor to actor Doug Hutchison, Teigen tweeted and privately messaged her urging her to kill herself.