It is located in Salina, Kansas, United States, and has been listed on the National Register of Historic Places since 2010.

Episcopalians initially met in Salina in the general store as well as in church buildings of other Christian denominations.

Herman Batterson, was looking for a way to memorialize her husband and donated a large sum of money to build the present cathedral.

Philadelphia architect Charles Marquendent Burns, Jr., a personal friend of her husband, was to design the building.

[4] Also on the cathedral property is a parish hall built in 1948 and a two-story education and office building completed in 1956.

[3] The exterior of the cathedral is covered entirely of limestone quarried in Chase County, Kansas, about 95 miles to the southeast of Salina.

[3] The stone that was used for the entrance steps and the door sills was quarried in Lyon County, Kansas.

Also at the crossing at the entrance to the choir is a rood beam, which was put in place in 1918 as a memorial to the cathedral's primary benefactor, Sarah E. Batterson.

The original pipe organ in the choir was built by Henry Pilcher's Sons, of Louisville, Kentucky.

The center panel features the symbol of Christ the Savior and is flanked by the Alpha on the left and Omega on the right.