[3] The priory buildings later housed Christ's Hospital school, founded by Edward VI,[3] and the church became its pupils' principal place of worship.

Reconstruction was assigned to Wren, who oversaw a decades long programme to rebuild St. Paul's Cathedral and approximately 50 parish churches.

The parish was united with that of St Leonard, Foster Lane, which was not rebuilt[3] Parishioners raised £1,000 to begin work on the design.

[3] The tower, rising from the west end of the church, had a simple round-arched main entranceway and, above, windows decorated with neoclassical pediments.

The interior was divided into nave and aisles by Corinthian columns, raised on tall plinths so that their bases were level with the gallery floors.

[3][9] The north and south walls had large round-arched windows of clear glass, which allowed for a brightly lit interior.

The east end had trinity windows, a large wooden altar screen and a carved hexagonal pulpit, reached by stairs.

A pavement of reddish brown and grey marble to the west of the altar rails was said to date from the original gothic church.

Galleries stood over the north and south aisles, built at special request of the officers of Christ's Hospital as seating for the school's students.

The organ, on the west wall over the main nave door, was built by Renatus Harris in 1690, according to a pre-war guide to the church.

The Lord Mayor attended an annual service to hear the Ancient Spital Sermon on the second Wednesday after Easter, placing his ceremonial sword in a special holder.

Sixth Form boys tasked with maintaining order sat in special seats placed over those of the younger students.

In its final years, the congregation continued to drop in size, a common trend for City churches as people relocated to suburban neighbourhoods of London.

At Christ Church, the only fitting known to have been saved was the cover of the finely carved wooden font, recovered by an unknown fireman who ran inside as the flames raged.

The roof and vaulting collapsed into the nave; the tower and four main walls, made of stone, remained standing but were smoke-scarred and gravely weakened.

In 2002, the financial firm Merrill Lynch completed a regional headquarters complex on land abutting to the north and the west.

The nave area continues as a memorial; the wooden font cover, topped by a carved angel, can today be seen in the porch of St Sepulchre-without-Newgate.