It was traditionally the largest political party of Flanders, until it was overtaken by the New Flemish Alliance (N-VA) in the 2010s.

At the end of the century, the new fraction of Christian democrats shifted the focus of the party slightly to the left.

The CD&V led the subsequent coalition talks, which repeatedly stalled (see 2007–2008 Belgian government formation).

From 30 December 2008 till 25 November 2009, Herman Van Rompuy led his first cabinet before becoming the first permanent president of the European Council.

In June 2009, Flemish elections were held and the CD&V remained the largest party of Flanders.

The federal elections of 2010 resulted in a major loss of historic proportions for CD&V, largely due to votes lost to the Flemish-nationalist New Flemish Alliance.

The party places a strong emphasis on well-being and health care, as well as the pursuit of an equitable income for all citizens.

However, on the ethical front, CD&V holds conservative positions, particularly on issues such as abortion and euthanasia, where the party is reluctant to fast-track relaxations.

Combining these conservative ethics with progressive socioeconomic policies, CD&V is often considered a "centre party".

In its administrative activities, CD&V nurtures close ties with civil society, including trade unions, professional federations and various associations.