Christian III, Count Palatine of Zweibrücken-Birkenfeld (Strassburg, 7 November 1674 – Zweibrücken, 3 February 1735) was a German nobleman.

He was the son of Christian II of Zweibrücken-Birkenfeld and Katharina Agathe, Countess of Rappoltstein.

He was the only son of Christian II, Count Palatine of Zweibrücken-Birkenfeld to survive into adulthood.

He left the army and took up administration of Zweibrücken-Birkenfeld, which was a small part of the County of Sponheim.

In 1731, Count Palatine Gustavus Samuel Leopold of Zweibrücken died childless and Christian III inherited his territory.