[1] A versatile midfielder, Manfredini is a product of the Juventus youth system and spent the early years of his career sent on loan by Juve to smaller clubs.
In 2000, Manfredini joined ChievoVerona, and was an important part of the first ever Chievo side to reach Serie A, along with Eriberto formed the "back arrow" as both wings.
The team continued to surprise as they found themselves top of Serie A, eventually finishing fifth and achieving a UEFA Cup place.
Manfredini also scored a goal in the UEFA Champions League against German side SV Werder Bremen.
[8] In the season 2012–13 he played for Agropoli, newly promoted in Serie D. In 2006, Manfredini was handed his maiden national team callup by his country of birth, Ivory Coast.