The following year, they established the North Indian School of Medicine for Christian Women, the first of its kind in Asia.

In 1952, it was changed to Christian Medical College to enable it to admit both men and women students for the upgraded MBBS course which came into effect for its first admission from 1953.

At present the college offers degrees in all major speciality and superspeciality services and is affiliated to Baba Farid University of Health Sciences.

[14] In 1994, micro surgeon Abraham Thomas successfully reattached the avulsed face and scalp of a nine-year-old girl, Sandeep Kaur.

[19] Led by the Governing body, CMC Ludhiana has the following colleges associated with it: Admission procedure into the college is through NEET (UG) and NEET (PG), an Indian nationwide entrance examination conducted by the National Testing Agency (NTA) for admission in undergraduate and post graduate medical programs.

[20][21] The exam is mandatory for admission in medical programs of the college and invites over a million applicants annually.

[22][23] In 2023, India Today ranked CMC at 10th for private medical colleges in the country with lowest fees.

[32] The department offers de-addiction services and has found that most patients are between 20 and 30 years old and are addicted to anything from cough syrup and heroin to cocaine and alcohol.

[33] CMC Ludhiana provides health care and education in urban and rural communities through clinics and medical camps.

[34] Clinics in surrounding villages like Lalton Kalan, Rauwal, Malsihan Bhaike, Hambran are organised and managed under this program.

[4] Majority of the buildings such as college chapel and hospital block are constructed during British Raj times and are well preserved.