A member of the Republican Party, Miele served as the deputy secretary of the Maryland Department of Disabilities in the administration of Governor Larry Hogan from 2019 to 2023.

[2] Miele was raised in New Jersey and graduated from St. John Vianney High School, afterwards moving to Maryland to attend Towson University,[3] where he was a member of the Sigma Pi fraternity and earned a Bachelor of Science degree in political science in 2004 and a Master of Arts degree in professional studies in 2008; and Emory University, where he was a member of the Phi Alpha Delta fraternity, served as the president of the Federalist Society for Law and Public Policy Studies, and earned a Juris Doctor degree in 2014.

[5][6] While attending Emory, he co-founded and worked as the editor-in-chief for the Emory Corporate Governance and Accountability Review law journal,[1] interned for the U.S. Department of Justice's criminal division, and clerked for Maryland Court of Appeals justice Glenn T. Harrell Jr.[5] Miele was admitted to the Maryland Bar in 2017, after which he worked for injury law firm Pinder Plotkin LLC, first as an associate from 2017 to 2023 and then as a partner since 2023.

During his 2014 House of Delegates campaign, he expressed support for legislation to legalize same-sex marriage in Maryland, decriminalize marijuana possession, and repeal the death penalty.

[3] The election was seen as one of the most competitive in the Maryland Senate, as Miele was expected to benefit from having Hogan's endorsement, who won the district by 37 points in 2014,[14][15] but Klausmeier was seen as being the slight favorite due to her high name recognition and strong community roots.

[25] Following his defeat, in December 2022, Governor Larry Hogan appointed Miele to the Maryland Senate to replace Cassilly, who vacated the seat after winning the Harford County executive election.