Von Stetten is a member of the Christian Democratic Union, one of the parties in the present grand coalition government led by Chancellor Angela Merkel.

[4] In the negotiations to form a Grand Coalition of the Christian Democrats and the Social Democrats (SPD) following the 2013 federal elections, von Stetten was part of the CDU/CSU delegation in the working group on financial policy and the national budget, led by Wolfgang Schäuble and Olaf Scholz.

"[5] On February 27, 2015, he voted against the Merkel government’s proposal for a four-month extension of Greece's bailout; in doing so, he joined a record number of 29 rebels from the CDU/CSU parliamentary group who expressed skepticism about whether the Greek government under Prime Minister Alexis Tsipras could be trusted to deliver on its reform pledges.

[7] Ahead of the final vote on Greece's third bailout plan in August 2015, Stetten stated that "a temporary Grexit remains the right solution.

"[8] Ahead of the Christian Democrats’ leadership election in 2018, von Stetten publicly endorsed Friedrich Merz to succeed Angela Merkel as the party's chair.