On June 10, 2016, Grimmie was shot dead while signing autographs following a concert performance at The Plaza Live in Orlando, Florida.

[20] Grimmie's covers first gained attention and stood out due to her voice, personality, and interpretations[21] of well-known songs.

Grimmie appeared on the Billboard Social 50;[30] she also opened for Selena Gomez & the Scene, Allstar Weekend and the Jonas Brothers during the Concert of Hope.

She appeared on The Ellen DeGeneres Show with fellow YouTuber Tyler Ward, performing a cover to Lil Wayne's "How to Love"; the episode aired on October 10.

[37] Grimmie was the special musical guest performing her hit song "Advice" on Disney Channel's So Random!, which premiered on December 11.

[38] In January 2012, Grimmie moved to Los Angeles to pursue her singing career; she was signed in April to Creative Artists Agency.

[39] A stripped version of Grimmie's original song "Find Me" was released on ITunes in June,[40] and reached the front page later in July.

She then opened for Gomez during the North American leg of her Stars Dance Tour,[46] performing songs from her debut album With Love, which was released on August 6, 2013.

Grimmie said the video is "about a guy that I start liking in school, and he's sort of a dangerous kid, and I am the type of girl that tells my mom about everything.

In September, she was one of 16 international artists, including Paul McCartney, to record the charity single "Love Song to the Earth", which raises climate change awareness.

The televised ceremony caused backlash among her fans, who said her name was used to promote the show, but never mentioned during the broadcast despite the inclusion of a tribute to victims of gun violence.

Grimmie cited Christina Aguilera as her main influence vocally, and listed her favorite singers as Celine Dion, Whitney Houston, and Lady Gaga.

Grimmie said she liked dubstep and DJ music, as well as rock 'n roll and heavy metal artists Metallica, Pantera, Iron Maiden, System of a Down and Tool.

[8] Grimmie had cited her mother, Tina, a three-time breast cancer survivor, as a major inspiration for her musical career.

After CPR was performed on her by an attending physician, she was taken to the Orlando Regional Medical Center in critical condition;[119][120][b] by 10:59 p.m., she was pronounced dead.

[130] Police did not offer a motive,[d] but said that Loibl had shown an "unhealthy and unrealistic infatuation" with the singer and tried to make himself more physically attractive for her through weight loss, hair transplants, teeth whitening and eye surgery.

[137][e] On June 23, Billboard magazine published an open letter advocating gun control, addressed to the United States Congress, demanding that universal background checks become federal law, referring to Grimmie's death and also the Pulse nightclub shooting which killed 49.

[139][140] On August 21, NBC broadcast a post-Olympics preview episode of The Voice dedicated "in loving memory of our friend Christina Grimmie.

Longtime friend and former tour-mate Selena Gomez was performing only a few miles away from Grimmie at the Amway Center at the time of the murder.

[148] Many others dedicated performances to Grimmie, such as Justin Bieber, Sabrina Carpenter, Demi Lovato, Maroon 5, Twenty One Pilots, Charlie Puth, and Rachel Platten.

[152] Before You Exit, with whom Grimmie had performed before her murder, tweeted, "Today we lost an angel, sister, and a beloved friend.

"[153] The family of the perpetrator of Grimmie's death left a handwritten note on their doorstep offering their condolences and apologies for their son's actions, with "no other comments".

[170] Grimmie's death led to calls for increased security at performing arts venues,[171] and also created a discussion about gun control and mental health.

[172][173] American heavy metal band Pantera, noting the similarities between Grimmie's murder and the deaths of former Pantera guitarist Darrell Abbott and three others in 2004, urged concert promoters and club owners to impose stronger measures to protect artists from "gun-wielding fanatics", adding: "Sadly, that's not the case and another rising star had to pay the consequences with her life.

[177] In California, VidCon added metal detectors and security officers, and banned informal meet-and-greets in the wake of Grimmie's murder.

[186] Grimmie's death was the inspiration for the 2022 song "Glimpse of Us", co-written by her close-friends Connor and Riley McDonough of Before You Exit (along with Alexis Kesselman and Castle) and released by Japanese-American singer-songwriter Joji.

The song was originally created as a voice memo by Riley McDonough in 2019 to cope with Grimmie's death, as during recording he "[called] out to God, [asking], "If I could only catch a glimpse of you."

[187] In December 2016, six months after her murder, Grimmie's family filed a wrongful-death lawsuit in Florida circuit court against several entities, including the concert promoter, the foundation that owns the venue, and the security company working the event.

[191] On April 9, 2018, just short of a year after the Grimmie family filed a new complaint in a Florida court, it was revealed that a judge rejected the defendants' AEG Live and the Orlando Philharmonic Orchestra Plaza Foundation motions to dismiss the case, and allowed the family's lawsuit to move forward.

[192] In their lawsuit, the Grimmie family alleged that the defendants had "failed to take adequate security measures to ensure the safety of the performers and the attendees at the concert venue."