As Gambito has stated repeatedly in her videos, she is notably one of the very few top users who are acting, filming, editing and producing her shorts completely on her own.

[8][9] Born of Filipino ancestry and raised in the United States, she was involved in cameo appearances and small parts of television commercials, movies, and industrial and training films.

[13] Her first sketch, Instant vlogging,[14] was originally broadcast on September 6, 2006 and featured Gambito impersonating four different characters, each representing a different video blogging style.

Her second video introduced many of the recurring themes in her following sketches, such as her parents' attitude towards her growing popularity over the Internet and her family's ethnic habits seen through the mind of an American.

[17][18] Gambito has collaborated with fellow YouTube comedian Kevin Wu (KevJumba) and has made five videos with him.