Christine of Hesse-Kassel (19 October 1578 – 19 August 1658) was a German noblewoman member of the House of Hesse and by marriage Duchess of Saxe-Eisenach and Saxe-Coburg.

In Rotenburg an der Fulda on 14 May 1598, Christine married John Ernest, Duke of Saxe-Eisenach as his second wife.

In the marriage contract was stipulated, in addition to her paternal, maternal and fraternal inheritance, an income from her future husband.

Christine was described as a learned and pious woman, who being married to a Calvinist prince was forced to renounce her Lutheran faith against her will.

She was buried in the Georgenkirche, Eisenach;[citation needed] in her will, she left 6,000 guilders for the purpose of scholarship and alleviation of poverty.