He then studied singing with Martin Gründler and Karlheinz Jarius in Frankfurt at the Hochschule für Musik, with Carla Castellani in Milan, with Alois Treml in Stuttgart, and attended Hartmut Höll's lieder class.
Also recognized as an eminent recitalist, he regularly performs at the major recital venues in Paris, London, Brussels, Berlin, Cologne, Amsterdam, Salzburg, Zurich, Vienna, Barcelona and Geneva, as well as during his concert tours throughout Italy, Japan and North America.
He has made over 120 recordings, on major labels such as BMG, EMI, Deutsche Grammophon, Philips, Sony, Erato and Teldec.
He took part in the project of Ton Koopman and the Amsterdam Baroque Orchestra & Choir to record Bach's complete vocal works.
In opera, Prégardien has made stage appearances in major European houses, performing leading roles as Tamino, Don Ottavio, Tito, Count Almaviva, Fenton, and Monteverdi's Ulisse.