His 1996 book Tout contre Léo (Close to Leo) talks about HIV and is aimed at young adults; he made it into a film in 2002.

In 2005, he returned to Avignon to present Dionysos impuissant in the "In" Festival, with Joana Preiss and Louis Garrel playing the leads.

His 2006 film Dans Paris has led him to be considered by French critics as the heir to the Nouvelle Vague cinema.

For the Opéra de Lyon he directed Poulenc's Dialogues of the Carmelites in 2013, Debussy's Pelléas et Mélisande in 2015, and Verdi's Don Carlos in 2018.

[8][9] In the summer of 2020 Honoré's rehearsals of his stage production of Le Côté de Guermantes, based on the third volume of Proust's In Search of Lost Time, were interrupted by restrictions to combat the COVID-19 epidemic and it became impossible to present it at the Comédie-Française as planned.