Christopher Mintz-Plasse was born in Woodland Hills, Los Angeles, where he attended El Camino Real High School, performing on its improv comedy team.

[8][9] In 2008, Mintz-Plasse next appeared with Paul Rudd and Seann William Scott in David Wain's film Role Models as Augie Farques, a nerdy teenager obsessed with medieval live-action role-playing games.

Chris D'Amico, which was planned to be a minor role until director Matthew Vaughn saw Mintz-Plasse audition and his capabilities.

[13][14] In 2011, Mintz-Plasse appeared in Fright Night—a remake of the 1985 film—as Edward Lee, former best friend of Charley Brewster, played by Anton Yelchin.

[17] Mintz-Plasse found the role to be darker than any other he had portrayed to date, and hired an acting coach to help him with the more intense scenes.

[23] He and his Kick-Ass co-star Chloë Grace Moretz starred in a short segment, "Middle School Date", in the film Movie 43.

He also had small roles in Seth Rogen and Evan Goldberg's This Is the End, playing a fictional version of himself, and in the romantic comedy film The To Do List, with Aubrey Plaza.

[27] Mintz-Plasse had a supporting role as college fraternity student Scoonie in the 2014 hit comedy film Neighbors.