Serelis became the head coach of the Greek club Lavrio in 2005.
On April 14, 2022, he left Lavrio in order to join Panathinaikos, as an assistant of Giorgos Vovoras.
On February 21, 2023, Serelis returned to Panathinaikos to serve as the head coach for the remainder of the season, after the firing of Dejan Radonjić and the rest of his staff.
After valiantly leading the club through a very tumultuous period of internal problems and bitter defeats, both domestic and abroad, Serelis took a backseat and returned to an assistant position, following the hiring of three-time EuroLeague winner Ergin Ataman as the historic club's new head honcho, starting with the 2023–2024 campaign.
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