[3] She began her career at six years old when she was cast in several national tours of Broadway shows, including Annie, The Will Rogers Follies with Keith Carradine, and The Sound of Music with Marie Osmond.

Romano voiced Yuffie Kisaragi in the English version of the movie Final Fantasy VII Advent Children, as well as in the Disney/Square game Kingdom Hearts.

[13] Romano starred as Michelle off-Broadway in White's Lies at New World Stages in 2010, alongside Betty Buckley and Tuc Watkins.

[14][15] Romano penned a novel, Grace's Turn, for Disney literary subsidiary Hyperion, which received accolades by the New York Public Library (NYPL) as the 2007 Teenage Book of the Year.

[citation needed] Amongst other titles, Romano has appeared in many films since her Disney days including Lifetime's Deadly Daycare, Wes Craven's The Girl in the Photographs, Loosies, and Christmas with the Andersons.

Romano appeared as pop star Poppy Blu in the live action Kim Possible television movie which premiered on February 15, 2019.

[20] On November 15, 2024, Fox announced that Romano was one of fifteen contestants to appear in the third season of reality quasi-military training television series Special Forces: World's Toughest Test.

[24] In 2023, Romano launched a company called PodCo, a podcast network that focuses on rewatches hosted by the stars of popular TV series such as Wizards of Waverly Place, Ned's Declassified School Survival Guide, Even Stevens, and others.

[26] After her singing career, Romano began narrating audiobooks, including Pop Princess by Rachel Cohn, The Unbecoming of Mara Dyer trilogy by Michelle Hodkin, and Beautiful Blue World by Suzanne M.

[27] She also narrated audiobooks To Catch a Killer by Sheryl Scarborough, Futuristic Violence and Fancy Suits by David Wong, Kaleidoscope Hearts by Claire Contreras, and the Adventures of Owl Series by Kristi Charish.

[29] Her experience of playing Belle in Beauty and the Beast on Broadway was taxing on her voice, which was already in delicate condition after she had to have surgery to remove vocal nodules right before her audition.