[5] On 20 October she was stepped up in class for the Listed Ivy Stakes over the same distance at Tokyo Racecourse when she was the only filly in a ten-runner field and won by two lengths from Cosmo Calendula.

After starting slowly she was towards the rear for most of the race before making rapid progress in the straight and finishing second to the favoured Danon Fantasy, beaten half a length by the winner.

[8] On her first appearance as a three-year-old Chrono Genesis started 1.1/1 favourite for the Grade 2 Daily High Queen Cup (a trial for the Oka Sho) over 1800 metres at Toyo on 11 February.

After racing in mid-division Chrono Genesis was switched to the outside and produced a "powerful turn of speed" to take third place behind Gran Alegria and Shigeru Pink Dia.

[11] After a break of almost five months Chrono Genesis returned for the Shuka Sho over 2000 metres at Kyoto Racecourse on 13 October and started the 5.9/1 fourth choice in the betting behind Danon Fantasy, Curren Bouquetd'Or and Espoir.

[14] Restrictions imposed as a result of the COVID-19 pandemic meant that her next start, the Grade 1 Osaka Hai over 2000 metres at Hanshin on 5 April was run behind closed doors.

Starting the 4/1 fifth choice in a field of twelve she settled behind the leaders before heading the front-running Danon Kingly in the straight but was overtaken in the closing stages and beaten a neck into second place by Lucky Lilac.

[15] At the same track on 28 June Chrono Genesis was one of eighteen horses to contest the 61st edition of the Grade 1 Takarazuka Kinen and started the 3.1/1 second favourite behind the four-year-old colt Saturnalia while the other contenders included Lucky Lilac, Blast Onepiece, Glory Vase, Kiseki (Kikuka Sho), Wagnerian and Persian Knight (Mile Championship).

After settling in mid division, Chrono Genesis moved up on the outside to take second place behind Lucky Lilac on the final turn before gaining the advantage 300 metres from the finish and going clear of the field to win by six lengths.

"[16] After a break of over four months Chrono Genesis returned to the track in November and started second favourite behind Almond Eye in the autumn running of the Tenno Sho over 2000 metres at Tokyo.

[17] In the poll which is used to select the field for the Arima Kinen over 2500 metres at Nakayama Racecourse Chrono Genesis topped the list with 214,472 votes, the highest total in the race's history.

[18] On 27 December she started the 1.5/1 favourite for the Arima Kinen ahead of Fierement while the other contenders included Curren Bouquetd'Or, Lucky Lilac, World Premiere, Loves Only You, Kiseki, Blast Onepiece and Persian Knight.