[3][8] In December 2012, Akpom received his first call into the Arsenal senior squad, when he was an unused substitute for a 2–1 Champions League defeat to Olympiakos.

[15] Akpom's second Arsenal appearance came in a League Cup third round tie away to West Bromwich Albion on 25 September.

[14] He replaced goalscorer Thomas Eisfeld after 82 minutes and with the scores at 1–1 at full-time, the game entered extra time.

Akpom scored a hattrick in a 6–1 FA Youth Cup fourth round demolition of Peterborough United on 6 January 2014.

[16] On 30 December 2013, it was reported that League One sides Brentford, Peterborough United, Leyton Orient and Milton Keynes Dons were in a four-way battle to sign Akpom on loan.

[19] He missed the first match of his loan through illness[20] and Warburton stressed that Akpom would have to "work hard and earn his place like everyone else".

[14] Akpom began the 2014–15 season by scoring a hat trick for Arsenal in an Under-21 Premier League Division 2 game against West Bromwich Albion at the end of August.

[26] On 23 September 2014, he made his first senior appearance of the season, replacing Héctor Bellerín for the last four minutes as Arsenal lost 1–2 at home against Southampton in the League Cup.

[28] On 4 February 2015, Akpom spurned the interest of a number of other clubs from the Premier League and across Europe to sign a new 4+1⁄2-year contract with Arsenal.

[32] Akpom made his debut for the Yorkshire based club on the opening weekend of the 2015–16 season scoring the second goal in a 2–0 home win to Huddersfield Town on 8 August.

[33] Akpom made his second appearance from the bench replacing Nikica Jelavic in the 60th minute in the League Cup first round against Accrington Stanley.

[33] On 30 January 2016 Akpom scored his first senior hat-trick in the FA Cup match away to Bury that Hull won 3–1.

[33] He was an unused substitute in the 2016 Championship play-off final at Wembley as Hull beat Sheffield Wednesday to gain promotion to the Premier League.

[43] He was an unused substitute on 21 April 2019 when PAOK beat already relegated Levadiakos to confirm their first Super League title in 34 years.

[45] On 6 August 2019, he scored against Ajax in the first leg of their UEFA Champions League third qualifying round tie that ended as a 2–2 draw.

[47] On 1 March 2020, receiving a great pass from Omar El Kaddouri inside the penalty area, Akpom cut to a shooting position, subsequently whipping an excellent effort beyond the opposing goalkeeper, to open the score in a frustrating 1–1 away draw against Xanthi F.C.

[52] Chuba continued his fine run of form on Boxing Day 2022 when he netted his first hat-trick for the club in a 4–1 win over Wigan Athletic at the Riverside Stadium.

[53] On 5 January 2023, head coach Michael Carrick announced that the club had exercised a twelve-month contract extension with Akpom having scored thirteen goals in twenty matches.

[60] On 16 August 2023, Akpom signed for Dutch Eredivisie club Ajax on a five-year contract set to expire in June 2028.

[70] On 13 October 2015, Akpom made his England U21 debut playing 90 minutes and scoring with the last kick of the match in a European qualifying win over Kazakhstan.