Negron and his twin sister, Nancy, were raised by their mother, who placed them in a daycare facility while she supported her young children.

Though Negron refers to this facility as an orphanage, it was a mansion in the Bronx that contained a swimming pool, gymnasium, arts and crafts and more.

Negron grew up in the Bronx, where he sang in local doo-wop groups and played basketball both in schoolyard pick-up games and at William Howard Taft High School.

In 1967, singer Danny Hutton invited Negron to join him and Cory Wells to found the band Three Dog Night.

The group became one of the most successful bands of the late 1960s and early 1970s, selling approximately 60 million records and earning gold records for singles that featured Negron as lead singer, including "One," "Easy To Be Hard," "Joy to the World," "Old Fashioned Love Song" and "The Show Must Go On.

In July 1975, the British music magazine NME reported that Negron had been arrested for cocaine possession in Kentucky.

[18] In 2017 he noticed his oxygen levels dropping onstage, his doctor advised that continuing to perform under these conditions could put him at risk of heart attack or organ failure.