Chuprene Glacier (Bulgarian: ледник Чупрене, romanized: lednik Chuprene, IPA: [ˈlɛdnik t͡ʃoˈprɛnɛ]) is a 2.1 nautical miles (3.9 km; 2.4 mi) long glacier draining the northwest slopes of Imeon Range on Smith Island in the South Shetland Islands, Antarctica.

It is situated northeast of Bistra Glacier, southwest of Yablanitsa Glacier and northwest of Krivodol Glacier, Pashuk Glacier and Rupite Glacier, and flows southwest of Drinov Peak and Popovo Saddle, and west of Slatina Peak and Varshets Saddle southwestward along the northwest slopes of Antim Peak and Evlogi Peak into Drake Passage south of Villagra Point and north of Garmen Point.

The glacier is named after the settlement of Chuprene in northwestern Bulgaria.

This article includes information from the Antarctic Place-names Commission of Bulgaria which is used with permission.

This article about a glacier in Smith Island is a stub.