Church of Saint Mary of the Latins

In the 12th century, Crusader historian William of Tyre writes about the existence of a monastery, belonging to the people of Amalfi, which took charge of the hospital and its chapel.

Neither his homeland, his family, nor his education are known, yet according to all indications to date, it is he who founded the Order of Knights of the Hospital of Saint John of Jerusalem (Latin: Ordo Fratrum Hospitalis Sancti Ioannis Hierosolymitani), also known as the 'Order of Saint John', 'Knights Hospitaller', etc.

The "great" church[dubious – discuss] was allegedly sacked by Saladin after the fall of Jerusalem.

Confusingly, there were two Crusader-era Churches of St Mary in close proximity to each other in the Hospitallers' Quarter.

The remains of St Mary Major have completely disappeared under the 1901 Greek Aftimos Market.