[1] The church belongs the Greek Orthodox Prelacy, the Diocese of Aleppo.

The church was mentioned in an Armenian manuscript written by Movses Vardapet as one of three churches that were enlarged and renovated in 1499–1500 by the donation of an Armenian elite named Reyis Baron Yesayi.

The two others being the Forty Martyrs Armenian Cathedral and the old Saint Elias Maronite Church.

[4] The cathedral is home to many valuable icons of the famous Aleppine school.

By January 2020, the church was undergoing a comprehensive restoration as it was badly damaged by militants through the Battle of Aleppo in 2015.