The Church of the Holy Cross (Spanish: Iglesia de la Santa Cruz) is a Roman Catholic church in the Spanish city of Cádiz.

It was the cathedral of the Diocese of Cádiz y Ceuta between 1602 and 1838, when the new Cádiz Cathedral was completed.

[1] Originally built in 1262 after the conquest of the city by Alfonso X, it was completely rebuilt by 1602 after the first building was burned down by a combined Anglo-Dutch fleet commanded by Admiral Edward Howard, who sacked Cádiz in 1596.

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