The Church of the Holy Family is a Roman Catholic parish located in New Rochelle, New York, United States.

The church is ethnically and linguistically diverse, reflecting the demographics of its surrounding area, as it draws considerable numbers of Caribbean, Southeast Asian, African, and Italian parishioners.

Andrew Roche, celebrated mass in a former butcher shop and lived at the College of New Rochelle, traveling back and forth by foot.

The Holy Family School was opened in 1921 for first and second grade students in the basement of the church, with pews used to form a makeshift classroom.

A purpose-built school was opened in 1922 above the church with eight classrooms and was gradually expanded as enrollment increased.