The current church of the Holy Mother of God is considered the continuation of the historic church of the Holy Mother of God of the old Christian Jdeydeh quarter, which was opened in 1429 and operated until the beginnings of the 20th century, within the courtyard of the Forty Martyrs Cathedral of Aleppo, when it was turned into a library and recently to the Zarehian Museum in 1991.

[2] The ground-blessing ceremony took place on 10 September 1972 with the presence of Khoren I, Catholicos of the Holy See of Cilicia, during the period of Bishop Datev Sarkissian.

The church has a large hall opened in 1987 with a stage downstairs, used for cultural meetings, concerts, seminars and celebrations.

In 1993 a Khachkar-memorial by Sarkis Balmanougian was erected in the right side of the main entrance of the church, to commemorate the victims of the Armenian genocide.

Adjacent to the church is the Armenian Gertasirats High School and the Zohrab Kaprielian Theatre.