It belongs to the Zamość deanery of the Diocese of Lublin and Chełm [pl] of the Polish Orthodox Church.

The Orthodox church in Tarnogród was established in the early years after the town's founding, toward the end of the 1560s.

The temple is located in the central part of the village, west of the town square,[1] on Cerkiewna Street.

[3] For the Orthodox parish, King Sigismund II Augustus allocated half a lan of land when issuing the founding act.

[6] The struggle for control over the diocese lasted from 1610 to 1652, during which individual parishes decided on their own which bishop they recognized as their superior.

According to Marian Bendza [pl], the local parish remained under this jurisdiction until 1772,[7] officially adopting the union in 1773.

[2] A description from 1763 notes that it had a single dome[8] and five altars dedicated to Deesis, Christ the Savior, the Holy Trinity, the Blessed Virgin Mary, and Saint Nicholas.

[9] In 1773, the Tarnogród church was once again renovated and survived until the early 19th century, when it was replaced by a new wooden structure.

[2] Repairs to the church were funded by parishioners' donations, as its patrons failed to show sufficient initiative in this regard.

[10] During the 18th century, the Tarnogród church became a center for the veneration of an icon of the Blessed Virgin Mary, considered miraculous.

[15] In 1856, the Orthodox residents of Tarnogród appealed to the Zamoyski family entail for assistance in constructing a church, as they lacked the necessary funds.

In 1860, the civil governor of Lublin supported the initiative and designated an empty plot of land for the church's construction.

[16] The construction of the Orthodox church was completed before the January Uprising, making Tarnogród one of the centers of Orthodoxy in the region even before the Conversion of Chełm Eparchy in 1875.

[a][16] However, the dedication of the new church did not occur until 1872, performed by Bishop Flavian Gorodiecki [pl] of Chełm and Warsaw.

[20] Special attention was given to incorporating distinct East Slavic elements in the architecture of these sacred structures.

At that time, the Tarnogród parish was estimated to have about 340 members,[2] though another source suggests only 100 Orthodox believers remained.

[2] Through the efforts of the parish priest, Father Włodzimierz Klimuk, a comprehensive renovation of the church was carried out between 1995 and 1999.

The central part of the cross is higher, covered by a four-pitched tent roof, above which rises an octagonal ridge turret topped with a small onion dome.

[18] In 2010, Archbishop Abel Popławski of Lublin and Chełm established a local feast in his honor, celebrated in Tarnogród on November 11.