The church is located on Rue Es-Siaghine, just west of the Petit Socco square at the center of the Tangier medina.

[4]: 79  Construction started in October 1880, with funding from the Spanish government and the Obra Pía.

[5]: 208  It was complemented in 1892-93 by the edification of a clock tower, originally topped with a spire and later changed to the present-day cupola.

[2]: 769  The church initially served the whole city's Catholic community, including European diplomats.

More recently, the property has been used by the Missionaries of Charity who in 1996 altered its interior, partitioning the former church nave into two floors.