The congregation was founded in 1846, and the current sanctuary, built in 1912–1915, was designed by Bertram Grosvenor Goodhue in the Gothic Revival style.

[2] The Church of the Intercession and its Tudor Revival vicarage were designated New York City Landmarks in 1966,[3][4] and the complex was added to the National Register of Historic Places in 1980.

[2] The congregation's next church was a stone building designed by Rembrandt Lockwood[7] and located at 158th Street and Grand Boulevard, which is now Broadway.

[8] However, dissension within the congregation suppressed financial support for the parish, which became insolvent; the church was attached by the sheriff, and services proceeded only on the sufferance of the authorities.

[3] The church was built by Edward A. Wehr of Pittsburgh, who considered this his finest piece of work.