The Church of the Most Precious Blood is a Roman Catholic church in the Archdiocese of Southwark in the Pastoral Care of the Personal Ordinariate of Our Lady of Walsingham, situated on O'Meara Street in Southwark, London, SE1.

It is made from Sicilian marble and stands in a niche lined with flint from Norfolk.

[3] The church serves the Parish of the Most Precious Blood which was established in 1891 by the Bishop of Southwark, John Baptist Butt, upon a bequest of £10,000.

[3] Denis Evinson, in his book Catholic Churches of London, described the interior as "...a joy to enter, warm, welcoming and uncluttered by busy detail".

[3] The Stations of the Cross that adorn the walls of the interior were made from terracotta by the Swiss artist Matthias Zens [nl].