He is notable for his service in the United States House of Representatives from 1821 to 1839, including terms as chairman of several high-profile committees.

[1] Intending to begin a career as a businessman, Cambreleng worked as a clerk in a mercantile counting room.

[2] After the death of his employer, Cambreleng intended to pursue a business opportunity in New Orleans, but was unable to remain there because of ongoing combat during the War of 1812.

[2] Cambreleng traveled throughout Europe and Asia while handling commercial opportunities for himself and Astor, and he eventually became wealthy as a result of his business success.

[1] He attended the 1848 Democratic National Convention in Baltimore as a Barnburner but withdrew with his faction, and participated in the nomination of Van Buren as the candidate of the Free Soil Party.