The school hosts about twenty co-ed sports, with New York State Championship titles in men's cross-country running in 1989, 1995, and 1996, and in girls softball in 1989, 1999, 2004, 2006 and 2013.

In 2009, the Cicero–North Syracuse High School Varsity Winterguard were crowned as the WGI SA Class Champions, winning the National Title for the first time, with a nearly perfect score of 97.4.

The varsity team took first in Scholastic Open and received the bronze medal at WGI World Championships in Dayton OH.

[11] In 2022, the band led an undefeated in-state season, taking home 1st place in the national class with a score of 96.8.

The band traveled to the USBands Open Class National Championship in New Jersey and received 3rd place with a score of 94.0.