This clan are primarily settled in Somaliland, including Maroodi Jeex, Togdheer, Sahil, Awdal, Djibouti, Yemen, Ethiopia, as well as Kenya.

The Isamusa have produced many prominent Somali figures with the deputy secretary general of the United Nations Abdulrahim Abby Farah

[5] The Italian explorer and geographer Luigi Robecchi Brichetti had a similar remark in aspect of the valuable caravan trade, where he also mentioned the kindred Ayal Ahmad Sacad Muse and Mohamed Issa Ciise Muse, both from the Habr Awal tribe - who reserved the title as the Abban of Berbera.

[8]The Issa Muse, along with the wider Habr Awal clan family, formed the majority of the Somali merchants who frequented Aden and other Southern Arabian ports.

They bring from Harrar and the Galla country, coffee, saffron (bastard), tusks (ivory), and feathers, taking away in return zinc, brass, broad cloth, and piece goods.

They have agents at Berbera, and as opportunities offer, batches of, say, ten oxen or two hundred sheep are brought down for export, marching by easy stages.

[10]The Issa Muse have produced many prominent Somali figures with the Undersecretary General of the United Nations Abdulrahim Abby Farah, the first Somali Prime Minister & second President of Somaliland Muhammad Haji Ibrahim Egal, former vice President of the Somali Democratic Republic and of the 1/5 of the Supreme Revolutionary Council General Ahmed Mohamoud Farah, former vice president of Somaliland Ahmed Yusuf Yasin and the second tallest man in the world Hussein Bisad.