It was designed by the firm of Lockwood Greene and Company and completed in 1926.

[2] Built primarily of limestone,[3] and measuring fourteen stories tall, the Enquirer Building was built to house both commercial offices and publishing facilities.

[2] Lockwood Greene's architects designed the building in a mixture of architectural styles;[1] among its most distinctive features include the first-floor storefronts, the recessed central main entrance, and marble stonework with a Christmas tree with bronze details.

[3] The newspaper's printing facilities moved to a new property at the intersection of Western Avenue and Liberty Street in 1979, and the offices to 312 Elm Street in 1992.

[5][6] In 2015, the Cincinnati Enquirer Building was divided into two hotels, each containing over 100 rooms.