[6] Sampson was cast by Hank White to play Kelly Stone in his feature film Charlie Zone.
Sampson appeared in season 3 of Supernatural as the character Lisa Braedon, in the episode "The Kids Are Alright" in 2007.
In 2015, Sampson appeared in three episodes of Rookie Blue, a Canadian police drama television series starring Missy Peregrym and Gregory Smith, followed by eight episodes as Sophie Hale in the third season of the Canadian-British co-production Rogue, which stars Thandie Newton and Cole Hauser.
Sampson's other appearances include Reaper, The Last Kiss, Being Human, Footsteps, Proof of Lies, Pretty Dead Flowers, and Swamp Devil.
She also portrayed Sandra MacLaren in Rumours as well as the "Strong Brushing Arm" woman in a commercial spot for Listerine mouthwash.