In May 1627, after an unhappy love affair with his young cousin Taddea Colloredo (the ‘Nicea’ to whom much of his verse is addressed) he enrolled in the Order of the Knights of Malta.

After the death of his mother (1633), he resettled permanently in San Daniele del Friuli, where he chose to live a life of relative seclusion and study, gaining a reputation for dignity and probity of character.

He maintained continual correspondence with several Italian writers and scholars of the period and made occasional visits to Padua and Venice, where he became a member of the Accademia degli Incogniti and befriended Giovanni Francesco Loredan and Carlo de' Dottori.

Ciro di Pers wrote also a tragedy "L'umiltà esaltata, ovvero Ester regina", written around 1659 and published in Bassano in 1664.

Many occasional sonnets are descriptive vignettes in characteristic Marinist vein, enlivened by audacious imagery, dramatic adjectives, and neatly rounded conclusion.

Ciro di Pers is obsessed with an acute sense of suffering about time, which rapidly escapes and devours human life and its artifacts.