Cisse Sandra was born on 16 December 2003 in Bellegem, Kortrijk Municipality in West Flanders, where he attended Kinderland Sint-Anna primary school and participated in international football tournaments.
At the club level, he started playing youth football for KWSC Lauwe and Zulte Waregem.
[4] On 22 August 2020, Sandra made his debut for Brugge's reserve side, Club NXT in the Belgian First Division B against RWDM47.
[6] On 22 August 2023, Sandra signed for Eredivisie club Excelsior on a season-long loan deal.
[7] On 4 July 2024, Sandra joined newly promoted Eredivisie club Willem II on a season-long loan deal.