"Cities on Flame with Rock and Roll" is the debut single by American hard rock band Blue Öyster Cult from their eponymous debut album Blue Öyster Cult.

[5][6] Its demo is credited with getting the band signed with Columbia Records.

The lyrics describe the devastation of nuclear war with metaphors likening the destruction to rock and roll music.

Cash Box called it a "hard driving, heavy metal rocker will be immediately attractive to both AM and FMers looking to put some life into their playlists.

"[8] The song has been covered by Church of Misery (on Master of Brutality), Iced Earth (on Tribute to the Gods) and 3 Inches of Blood (as a bonus track on Here Waits Thy Doom).