In 1856 the firm built new quarters on 28th and 29th Streets near Fairmount Park and the Schuylkill River.

In 1881 the firm was incorporated as City Park Brewery.

Louis Bergdoff died in 1894, but the firm continued to operate as a brewery until Prohibition in 1920, and then for a single year after the repeal of Prohibition, in 1934.

A couple of blocks north of the historic district, at 929 North 29th Street, the Queen Anne style Louis J. Bergdoll House, built 1885, is listed separately by the NRHP.

The Italianate style Bergdoll Mansion, built in 1890 at 2201–2205 Green Street about 10 blocks southeast of the brewery, is also listed separately on the NRHP.