[4] City of the Dead was set on a fictional island called "Ningún Futuro" ("No Future" in Spanish).

A zombie outbreak occurs on the island after a series of secret military tests on cadavers backfires.

Reports had said there would be no reference in the game to Dawn of the Dead (because the 2004 version ends with the survivors winding up in a zombie-ridden island), one of the more popular films in the Dead Series due to copyright issues with the MKR Group who hold the rights to the film.

[5] Before the cancellation, it was announced that Tom Savini, make-up artist and regular actor in the Dead Series, would be providing the voice and likeness of a character in the game.

Those that saw the presentation have commented that City of the Dead contained exceptionally extreme amounts of graphic violence.