Opened in 1883 under the name East Perth, Claisebrook station is a busy junction along the Airport, Midland, Armadale and Thornlie lines due to both lines running through the station and the Claisebrook railway depot being next door.

The Battye library carries the original plans and shows exposed heavy timber trussing of the roof which was very typical of the architecture of railway buildings of the era.

The station was located centrally between the east and west bound tracks and provided access to both.

In 1984 the station was relocated to Whiteman Park to be the Central Station on the light railway system under construction in the majority by the Western Australian Light Railway Preservation Association and the Metropolitan Region Planning Authority funded under Wage Pause and Community Employment Programmes.

In 2024, Claisebrook station was identified as one of three stations to have its platform extended to 150 metres (490 ft) as part of phase one of the platform and signalling upgrade program to allow for six-car trains on the Ellenbrook line and Thornlie line.