Clarence Wiley "Doc" Spears (July 24, 1894 – February 1, 1964) was an American college football player, coach, and doctor.

Spears was inducted into the College Football Hall of Fame as a player in 1955.

Spears was born in DeWitt, Arkansas and attended high school in Kewanee, Illinois.

Spears was the head coach for the Dartmouth Indians football team from 1917 to 1920.

While coaching, Spears studied medicine at the University of Chicago and the Rush Medical College.