Clarisse Machanguana (born 4 October 1976) is a professional women's basketball player and philanthropist from Mozambique.

In 2014 founded the Clarisse Machanguana Foundation, which empowers Mozambiquan youth through sport, education and health.

At the 2006 Lusophony Games, she led the Mozambique women's national basketball team to a gold medal.

[7] Local nonprofits approached her to represent them due to her name recognition and wide reach.

[9] In spring 2016, she began a trek across Mozambique to bring awareness to the country's HIV epidemic and obstetric fistula.

During the COVID-19 pandemic, Machanguana approached the U.S. Embassy in Mozambique for aid in obtaining a scholarship to learn about nonprofit management.